Guadeloupe travels on the right. The majority (1,742 km) of the region's 2,082 km of roads are paved and well-maintained. Road signs and directions are written in French because Guadeloupe is a French-administered territory. The highways N1 and N11 link Grande-Terre and Basse-Terre, the two main islands. In Basse-Terre, the mountain roads have particularly sharp turns, making winding roads common.

Karu'lis operates a number of bus routes throughout Grande-Terre, including direct services to and from Basse-Terre, as well as a limited route on the island of La Désirade in the north-eastern region.