TNT Express separated from its parent company, TNT NV, on May 26, 2011, when it was listed on the Euronext Amsterdam. PostNL was the new name given to TNT NV after that.

UPS announced in March 2012 that it would pay US$6.7 billion for TNT Express. However, in January 2013, it was revealed that UPS had been blocked on competition grounds due to its failure to obtain permission from the European Commission.

A TNT Express truck in Plymouth, England, in February 2010 FedEx announced in April 2015 that it had agreed to acquire TNT Express for €4.4 billion in an effort to expand its European operations. On January 8, 2016, the deal was approved after the planned acquisition was investigated by the European Commission. On May 25, 2016, the transaction was concluded.

The NotPetya cyberattack had a significant impact on TNT Express in August 2017, in part due to the fact that some of the company's operations and communication systems are based in Ukraine, the country from which the attack originated. For months, TNT had to operate using manual procedures, which resulted in extremely large backlogs. Completely lost records included some.

TNT Express is now just a trade from FedEx, as FedEx announced on December 1, 2021, that the fusion had been completed.